By Technology Networks –
Scientists created an immunity-proof CRISPR system that reveals hidden metastasis genes in mouse tumour models.
The immune system plays a crucial role in fighting tumours and metastases. Consequently, it is decisive to conduct cancer research in mouse models with an immune system that is as natural as possible – which is easier said than done.
Thanks to CRISPR/Cas9 technology, researchers can quickly create a pool of hundreds of tumour cells, each with a different gene switched off. When transplanted into mice, it becomes apparent which of these silenced genes influences the development and spread of cancer. Assisted by such CRISPR screens, scientists are able to identify valuable approaches for the development of new therapies.
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