By Genetic Engineering and Biotechnology News –
T cells are not able to create their cellular energy, called adenosine triphosphate or ATP, when they are inside a solid tumor. Now, researchers led by UNC Lineberger Comprehensive Cancer Center may have discovered the culprit behind T cells’ loss of energy. The new findings could be used to make multiple types of T-cell therapies more effective for patients.
Their findings are published in Cell Metabolism in an article titled, “Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment.”