News and Opinions
Disarming cancer stem cells’ shield makes immunotherapy more effective
by UChicagoMedicine - Immunotherapy has revolutionized cancer care by training the immune system to detect and destroy tumors. For many patients, it works very well in shrinking tumors and sending cancer into remission, an undetectable state of cancer. But that...
Vycellix Prepares for First-in-Human Study of Novel Allogeneic Cell Therapy Powered by Its Universal Cell Engineering Platform
By Vycellix - - Single-step CD45-engager technology shows robust immune evasion with functional persistence in pre-clinical models - Phase 1 study to evaluate ‘off-the-shelf’ natural killer cell cancer immunotherapy in the treatment of multiple myeloma BOCA RATON,...
Crispr gene-editing technology offers new hope for HIV cure but faces delivery challenges
By Tosin Thompson - Chemistry World - Two years ago, the UK became the first country to approve Casgevy, a Crispr-based therapy for the blood disorders sickle cell disease and β-thalassaemia. This year saw the world’s first personalised Crispr therapy for a baby boy...
CRISPR Gets an Invisibility Cloak
By Technology Networks - Scientists created an immunity-proof CRISPR system that reveals hidden metastasis genes in mouse tumour models. The immune system plays a crucial role in fighting tumours and metastases. Consequently, it is decisive to conduct cancer research...
The vital, overlooked role of body fat in shaping your health and mind
By Linda Geddes - NewScientist - f you melted down the average UK adult, you’d find around 22 kilograms (48.5 pounds) of creamy yellow fat – equivalent to around 88 blocks of lard, enough to fill two-thirds of a small suitcase or cast into 446 dinner candles. Melted,...
Nanoflowers rejuvenate old and damaged human cells by replacing their mitochondria
by James Cavin - Phys.org - Biomedical researchers at Texas A&M University may have discovered a way to stop or even reverse the decline of cellular energy production—a finding that could have revolutionary effects across medicine. Dr. Akhilesh K. Gaharwar and...
The world’s first personalized gene therapy
By Cold Spring Harbor Laboaratory - How does science make life better? Here’s one example spanning eons. There’s an adaptive immune system called CRISPR that has existed in bacteria for billions of years. Thanks to fundamental biology research, it is now being used to...
Bone Marrow Model Created Entirely from Human Cells
By Genetic Engineering and Biotechnology News - Typically, bone marrow research relies heavily on animal models and oversimplified cell cultures in the laboratory. Now, researchers from the Department of Biomedicine at the University of Basel and University Hospital...
Inflammation turns bone marrow into a breeding ground for disease
By Science Daily - Inflammation covertly rewires the bone marrow, enabling mutated stem cells to rise and setting the stage for future blood disease. Researchers discovered that chronic inflammation fundamentally remodels the bone marrow, allowing mutated stem cell...
Artificial intelligence and systems biology analysis in stem cell research and therapeutics development
By Stem Cells Translational Medicine - Background: Stem cell research has rapidly advanced during the past decades, but the translation into approved clinical products is still lagging behind. Multiple barriers to effective clinical translation exist. We hypothesize...
The resurgence of mesenchymal stem cell therapies
By Miranda McLaren - Clinical Trials Alerts - Mesenchymal stem cells have been explored across a wide range of diseases due to their potential to reduce inflammation and promote tissue repair and regeneration. BBG Advanced Therapies’ Rogelio Zamilpa, PhD takes us...
New nanotech method loads stem cells with extra mitochondria to recharge dying cells
by Aamir Khollam - Interesting Engineering - Texas A&M scientists used nanoflower-boosted stem cells to deliver extra mitochondria to weakened cells, restoring lost energy and improving survival under stress. Scientists at Texas A&M University say they may have found...
Scientists use stem cells to model rare genetic blindness in children
by Children's Medical Research Institute - MedicalXpress - Researchers at the Eye Genetics Research Unit at Children's Medical Research Institute (CMRI) are the first in the world to use stem cells to study one of the genetic causes of Leber Congenital Amaurosis...
We need to start thinking of AI as “normal”
By James O'Donnell - MIT Technology Review - As technologists frame AI as either utopian or dystopian, two researchers offer a third option. Right now, despite its ubiquity, AI is seen as anything but a normal technology. There is talk of AI systems that will soon...
Stem Cells Prevent Heart Failure After Heart Attack
By American Medical Journal - A NEW phase 3 clinical trial has revealed that stem cells can help prevent heart failure in patients recovering from acute myocardial infarction. The study found that intracoronary infusion of mesenchymal stem cells significantly reduced...
Engineered Bone Marrow Model Advances CRISPR-CAR T Research in AML
By Genetic Engineering and Biotechnology News - Scientists at the University of Glasgow developed a bioengineered bone marrow (BM) model that helped them to evaluate potential use of a combined CRISPR-CAR T cell therapy in the treatment of acute myeloid leukemia. The...
Scientists discover how hair cells can help heal skin faster
By Rockefeller University - ScienceDaily Scientists found that low serine levels spark a shift in hair stem cells, transforming them into wound-healing experts — with diet playing a possible role. Rockefeller scientists uncovered how hair follicle stem cells can...
Behind the FDA’s Elimination of REMS Program for CAR T-Cell Therapies
By Jonah Feldman, Frederick Locke, MD - Targeted Oncology - On June 26, 2025, the FDA announced the elimination of the Risk Evaluation and Mitigation Strategy (REMS) program that applied to 6 chimeric antigen receptor (CAR) T-cell therapies approved to treat patients...
What will be born of the marriage of de-extinction firm Colossal and animal cloning biotech Viagen?
By Paul Knoepfler - STAT - The company that claimed to revive the dire wolf continues to raise ethical questions De-extinction firm Colossal Biosciences announced Tuesday that it was acquiring animal cloning firm Viagen. The same day, retired NFL all-star Tom Brady...
SwRI-developed single-use 3D-printed bioreactor harvests induced Pluripotent Stem Cells
By Medical Life Sciences News - Southwest Research Institute (SwRI) has demonstrated a new application for its cell-expansion bioreactor to advance tissue engineering and cell-based therapies for treatment of injuries and diseases. SwRI scientists used the bioreactor...
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