News and Opinions
3D microgel device puts stem cells under pressure
Robert Lea - Advanced Science News - Scientists have developed a new 3D cell culture device made from soft, porous microgel particles that can mimic the effects of pressure on stem cells. This platform allows researchers to study and even influence how stem cells...
Assessment of immune modulation strategies to enhance survival and integration of human neural progenitor cells in rodent models of spinal cord injury
By Stem Cells Translational Medicine - Our study demonstrates the advantage of using genetically immunodeficient rodents over traditional pharmacological methods in cell therapy research for spinal cord injury (SCI). This approach preserves the integrity and...
Disruption of a single amino acid in a cellular protein makes breast cancer cells behave like stem cells
By Queen Mary University of London - New research led by Queen Mary’s Institute of Dentistry has found that changes to the intermediate filament (IF) protein, vimentin, were found to promote tumour growth. Vimentin is a type III intermediate filament (IF) protein...
Stem Cells in the Brain Use Childlike Signals to Trigger Regeneration
By Neuroscience News - Scientists have discovered that neural stem cells (NSCs) receive constant feedback from their daughter cells, influencing whether they remain dormant or activate to form new neurons and glia. This parent-child relationship helps regulate brain...
Researchers Make Breakthrough in Bioprinting Functional Human Heart Tissue
By Technology Networks - Researchers at University of Galway have developed a way of bioprinting tissues that change shape as a result of cell-generated forces, in the same way that it happens in biological tissues during organ development. The breakthrough science...
Tailoring cell therapies for diabetic metabolic phenotypes: a comparative study on the efficacy of various umbilical cord-derived cell regimens
By Stem Cells Translational Medicine Given the high heterogeneity of type 2 diabetes mellitus (T2DM), it is imperative to develop personalized stem cell infusion regimen for targeted metabolic phenotype in order to ensure optimal therapeutic efficacy. In this study,...
New study shows stem cell therapy ‘jump-start’ brain repair after stroke
by Gladstone Institutes - MedicalXpress - Every 40 seconds, someone in the United States has a stroke. For survivors of the most common type of stroke, called an ischemic stroke, only about 5 percent fully recover. Most others suffer from long-term problems, including...
Enhanced bone regeneration using mesenchymal stem cell-loaded 3D-printed alginate-calcium Titanate scaffolds: A Calvarial defect model study
By Science Direct - This study investigates the efficacy of a 3D-printed alginate composite scaffold enriched with calcium titanate nano powders and loaded with mesenchymal stem cells (MSCs) for bone regeneration in a calvarial defect model. Scaffolds (20 mm × 20 mm ×...
Penn researchers develop temperature-sensitive protein with applications in cancer cell therapy
By Megan Liu - The Daily Pennsylvanian - A group of Penn scientists has developed a new method to remotely control engineered cells inside the human body using heat. Led by bioengineer Lukasz Bugaj, the innovation introduces a temperature-sensitive protein called...
Korea permits stem cell therapies for arthritis, autoimmune diseases, and Parkinson’s patients
By Heo Ji-yoon - Chosun Biz - Korean patients gain access to innovative regenerative medical treatments after law changes. Next month, patients with severe, rare, and incurable diseases such as arthritis, autoimmune diseases, Parkinson's disease, and cancer will be...
New study shows stem cell therapy ‘jump-start’ brain repair after stroke
by Gladstone Institutes - MedicalXpress - Every 40 seconds, someone in the United States has a stroke. For survivors of the most common type of stroke, called an ischemic stroke, only about 5 percent fully recover. Most others suffer from long-term problems, including...
‘Fatty cartilage’ discovery set to revolutionize regenerative medicine
By Paul McClure - New Atlas - Researchers have discovered a new type of tissue, a soft and flexible ‘fatty cartilage’ that could revolutionize the treatment of traumatic injuries, birth defects, and cartilage-damaging diseases like osteoarthritis, rheumatoid arthritis...
UCLA scientists awarded $21.8 million in CIRM grants to advance novel stem-cell based therapies
by Linda Wang - UCLA Health - Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received $21.8 million in grants from the California Institute for Regenerative Medicine, the state’s stem cell agency, to develop...
Autologous Implants: The New Hope for Spinal Cord Injury Treatment
By Asaf Levon - Haaretz News - Can damaged parts of the spinal cord be replaced with functional nerve tissues? Matricelf aims to make this vision a reality with groundbreaking technology. In the company's laboratories in Nes Ziona, a team of about ten experts in...
Healthspan Compass – Vol. 9 – from Healthspan Action Coalition
By Eve Herold - Healthspan Action Coalition - Before we launch into news on the healthspan front, let’s acknowledge the elephant in the room. US health agencies, including the National Institutes of Health and the FDA, are currently in a state of limbo as the dust...
The compassionate team behind CAR T cancer breakthroughs
By: Nicole Sweeney Etter - Penn Medicine News - For more than a decade, Penn Medicine clinical research nurse Joanne Shea, MS, BSN, RN, has had a front-row seat to the groundbreaking research underway in the Center for Cellular Immunotherapies. As Abramson Cancer...
Youthful Brain Stem Cells Linked to Autism and Brain Cancer
By Neuroscience News - Researchers have identified a unique stem cell in the young brain capable of maturing into multiple cell types, potentially explaining the origins of autism and glioblastoma. These stem cells show gene expression patterns that regulate early...
JPM25: Bayer moves allogeneic cell therapy into phase 3 Parkinson’s trial
By Gabrielle Masson - Fierce Biotech - Bayer’s Parkinson’s disease cell therapy is moving into late-stage testing, with the upcoming trial set to be the first registrational phase 3 study for an investigational allogeneic cell therapy in the neurodegenerative disease....
10 Mayo Clinic research advances in 2024, spanning stem cell therapy in space to growing mini-organs
By Mayo Clinic - ROCHESTER, Minn. — At Mayo Clinic, researchers published more than 10,000 scientific papers in 2024 that are driving medical discoveries, leading to new cures for the future. The following are 10 research highlights from Mayo Clinic this year: Growing...
Princeton bioengineers shed light on how and when embryonic cells organize themselves
By Wright Seneres - Princeton Engineering - For decades, scientists have puzzled over how a symmetrical ball of cells becomes an embryo, with the beginnings of a head and tail. Now Princeton engineers have discovered that this transformation from perfect symmetry to...
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