News and Opinions
New Tool Identifies Proteins That Control Gene Activity
by Weill Cornell Medicine - he SCOPE system can capture proteins binding to regions of DNA that control gene expression. The illustration depicts part of the process where a small guide RNA delivers a protein bearing a special amino acid to the desired region....
This “chaos enzyme” may hold the key to stopping cancer spread
By Science Daily - A Weill Cornell Medicine team has found that triple-negative breast cancer depends on the enzyme EZH2 to spread. By silencing key genes, EZH2 drives chaotic cell divisions and fuels metastasis. Blocking EZH2 restored stability and prevented cancer...
Adult Stem Cells Improve Vision in Patients With Macular Degeneration
by Technology Networks - In a first-in-human Phase 1/2a clinical trial, adult stem cells improved vision in patients with macular degeneration. In the United States, age-related macular degeneration is a leading cause of irreversible vision loss in people who are 60...
Stem cells may offer new hope for end-stage kidney disease treatment
By Alison Satake - Mayo Clinic - More than 4 million people worldwide have end-stage kidney disease that requires hemodialysis, a treatment in which a machine filters waste from the blood. Hemodialysis is a precursor to kidney transplant. To prepare for it, patients...
Distal lung organoids derived from adult stem cells as novel tools in deciphering mechanisms of lung regeneration, infection, and cancer
By Stem Cells Translational Medicine - Introduction While lung research has made great strides in understanding lung physiology, lung pathology still presents a major burden to patients and healthcare systems globally. To develop new effective therapeutics to improve...
ISSCR Unveils Roadmap for Advancing Pluripotent Stem Cell-Derived Therapies
by Bioengineer.org - The International Society for Stem Cell Research (ISSCR) has unveiled an innovative and comprehensive resource entitled Best Practices for the Development of Pluripotent Stem Cell-Derived Cellular Therapies, marking a pivotal advancement in the...
This medical startup uses LLMs to run appointments and make diagnoses
By Grace Huckins - MIT Technology Review - Imagine this: You’ve been feeling unwell, so you call up your doctor’s office to make an appointment. To your surprise, they schedule you in for the next day. At the appointment, you aren’t rushed through describing your...
Lab-grown kidneys show real function in new stem cell study
By Drug Target Review - A USC Stem Cell-led research team have made a big breakthrough in their efforts to build mouse and human synthetic kidneys. In a new paper published in Cell Stem Cell, the scientists describe generating more mature and complex lab-grown...
New gene therapy slows progression of Huntington’s disease by 75%
By Sky News - It is likely to be the first licensed treatment to slow Huntington's, and that "changes everything", says lead investigator Professor Ed Wild. Known as AMT-130, it is delivered via brain surgery, and a single dose is expected to last someone's whole...
AI-designed viruses are here and already killing bacteria
By MIT Technology Review - Artificial intelligence can draw cat pictures and write emails. Now the same technology can compose a working genome. A research team in California says it used AI to propose new genetic codes for viruses—and managed to get several of these...
Junk DNA” Found to Sense Its Environment, May Hold the Key to Disease Treatment
By Bernadette Gillis - Duke university School of Medicine - A new study from Duke University School of Medicine has uncovered a surprising role for what was once considered “junk DNA.” Researchers found that these overlooked parts of our genetic code help stem cells...
Common Nutrient Found To Supercharge Immune Cells Against Cancer
By Chandrika Abburi, University of Chicago Medical Center - SciTechDaily - In a recent study, scientists at the University of Chicago found that zeaxanthin, a carotenoid derived from plants and traditionally recognized for supporting eye health, may also enhance...
Scientists use human skin cells to create functional eggs, opening a door to new infertility treatments
By Katie Hunt - CNN - Scientists have used human skin cells to create fertilizable eggs capable of producing early embryos, an advance that could expand possibilities for fertility treatment, according to new research. The proof-of-concept study, published Tuesday in...
Parkinson’s is on the rise. Here’s one future treatment giving researchers hope
By NPR - Parkinson's Disease affects around a million people in the United States, and that number is on the rise, in part because our population is getting older. Dr. Claire Henchcliffe is the chair of neurology at the University of California, Irvine. She's one of...
Stem cell transplant for stroke leads to brain cell growth and functional recovery in mice
by Wayne Lewis - Keck school of Medicine USC - When someone has a stroke — a leading worldwide cause of death and disability — time is of the essence. Almost nine out of 10 cases are ischemic strokes, caused by restricted blood flow in the brain, and the current...
New Targets Emerge for Aggressive Small Cell Lung Cancer
By Sabrina Serani, Matthew Oser, MD - Targeted Oncology - While there have been notable breakthroughs for the treatment of small cell lung cancer (SCLC) in recent years, there is still a relative dearth of targeted therapies for this aggressive subtype. Researchers...
Youngest Cedars-Sinai Stem Cell Donor Helps Doctors Treat Dad’s Leukemia
By Cedars Sinai - In July, Nick Mondek, MD, drove his healthy 9-year-old son Stephen to Cedars-Sinai on an important mission: To donate stem cells that might cure Mondek’s deadly blood cancer. Stephen’s donation would give Mondek a brand-new immune system—and make...
New stem cell approach could repair stroke-damaged brains
by Drug Target Review - A new experimental stem cell therapy shows promise in repairing brain damage after ischemic strokes – potentially allowing for the development of future treatments that extend the recovery window. Strokes are a leading worldwide cause of death...
CAR T’s biggest hurdle: solving the toxicity problem
By Drug Target Review - CAR T therapies are saving lives, but toxicities such as CRS and ICANS remain a major barrier. What will it take to overcome them? Chimeric antigen receptor (CAR) T-cell therapy is changing lives for patients with hard-to-treat cancers. By...
Evaluating the long-term efficacy of umbilical cord-derived mesenchymal stem cell therapy in retinitis pigmentosa: findings from a 1-to-4-year follow-up
By Stem Cells Translational Medicine - Background The objective of this study was to assess the long-term effectiveness and safety of implanting mesenchymal stem cells derived from umbilical cord tissue (UC-MSC) in patients diagnosed with retinitis pigmentosa (RP)....
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