By News Medical Life Sciences –
Bone regeneration continues to be a critical challenge in tissue engineering, with unpredictable outcomes often hindering clinical application. Current strategies overlook key factors such as donor differences and biological sex, both of which play a significant role in fracture healing. While cartilage intermediates have shown promise, the transition from cartilage to functional bone remains poorly understood, and a lack of quality metrics that are predictive of bone regeneration across patients hinder clinical implementation. Moreover, the influence of biological sex on bone repair, particularly in younger patients, remains an underexplored area. These challenges highlight the urgent need to understand how donor and sex-specific mechanisms affect bone regeneration.
