News and Opinions
New study shows promising evidence for sickle cell gene therapy
By Grace Niewijk - University of Chicago Medicine New research published in the New England Journal of Medicine indicates that stem cell gene therapy may offer a promising, curative treatment for the painful, inherited blood disorder sickle cell disease (SCD). The...
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by Sarah Anderson, PhD - Exploring Drug Discovery and Development Like a differentiated stem cell, Lonnie Shea’s strong foundation in fundamental cellular biology underwent just the right prompts to evolve into a proliferative biomedical research career. During...
Cell therapy that repairs cornea damage with patient’s own stem cells achieves positive phase I trial results
by Massachusetts Eye and Ear Infirmary A team led by researchers from Mass Eye and Ear, a member of Mass General Brigham, reports the results of a phase I trial of a revolutionary stem cell treatment called cultivated autologous limbal epithelial cell transplantation...
A Review of Human Disease Models in Drug Development
By Florina Gobel - Center for Contemporary Sciences In the article Human disease models in drug development published in Nature, the authors delve into the critical role of human disease models in drug development, emphasizing the importance of bridging the gap...
Modified neural stem cells for spinal cord injury
By Drug Target Review Using genetically modified human neural stem cells (hNSCs), researchers demonstrated that targeted manipulation of a specific gene expression within hNSCs can facilitate the restoration of damaged neural circuits and recovery of locomotor...
Wiping stem cells ‘clean’ could make them easier to produce
By Jason Arunn Murugesu - NewScientist A technique for reprogramming adult cells that removes any trace of their origins could help produce stem cells at larger scales A new way to turn adult human cells into ultra-flexible stem cells could make it easier to produce...
Building muscle in the lab
by Fabio Bergamin - ETH Zurich Professor Ori Bar-Nur and his team grow muscle cells in the laboratory. In this case, they are mouse cells, but the researchers are also interested in human and cow cells. Promising applications resonate with both: human muscle tissue...
How mRNA Could Safely Replace Blood Stem Cell Transplantation
by William A. Haseltine - Forbes At present, the only way to cure genetic blood disorders such as sickle cell anemia and thalassemia is to reset the immune system with a stem cell transplantation. Only a fraction of patients elects this procedure, as the process is...
Polyploid cells, which have extra copies of their genomes, may help tissues respond to injuries and species survive cataclysms
By Elizabeth Pennisi - Science When Vicki Losick got her Ph.D. and joined a fruit fly lab at the Carnegie Institution for Science in 2008, its head announced that he expected his postdocs to launch new fields of inquiry. She chose a then-fashionable focus: stem cells,...
Want to speed up scientific progress? First understand how science policy works
Researchers and policymakers often exist in different worlds and speak different languages. Here are three ways to bridge the divide. by Nature.com Science is a key driver of economic growth and social progress. If science can be accelerated — such as by increasing...
Using stem cells, doctors restored vision to people with devastating eye injuries
By Theresa Tamkins, Jessica Klingbaum and Kristen Dahlgren - NBC News Eye surgeons in the U.S. are inching closer to being able to use a specific type of stem cell transplant to fix a serious eye problem that can cause pain and permanent vision loss. It was the Fourth...
Scientists harness the power of AI to shed light on different types of Parkinson’s disease
by Frances Crick Institute Researchers at the Francis Crick Institute and UCL Queen Square Institute of Neurology, working with technology company Faculty AI, have shown that machine learning can accurately predict subtypes of Parkinson’s disease using images of...
Stem cell studies tune into hearing regeneration
by Keck School of Medicine of USC - MedicalXpress Image caption: Rows of sensory hearing cells (green) next to supporting cells (red) in the inner ear of a mouse. Credit: John Duc Nguyen and Juan Llamas/Segil Lab A deafened adult cannot recover the ability to hear,...
Stem Cell Therapy May Restore Fertility After Ovarian Failure
by Katie Brighton - Technology Networks With cancer rates among young adults on the rise, the number of people experiencing infertility as a result of chemotherapy is also expected to increase. Yet, there are currently no therapies available to restore fertility after...
New Method Developed To Reprogram Human Cells
by Monash University - Technology Networks News In a groundbreaking study published in Nature, Australian scientists have resolved a long-standing problem in regenerative medicine. Led by Professor Ryan Lister from the Harry Perkins Institute of Medical Research and...
Early Mayo Clinic research finds hope in stem cell therapy for perianal fistulas in patients with Crohn’s disease
By Susan Buckles – Mayo Clinic A dissolvable plug delivered stem cell therapy with few side effects in patients with single tract perianal fistulas, Mayo Clinic researchers discovered. Perianal fistulas are painful tunnels between the intestine and the skin that often...
Researchers find an epigenetic key that unlocks common deadly cancers
By Elaine Fuchs - Rockefeller University News Early on, every stem cell faces a fateful choice. During skin development, for instance, the embryonic epidermis begins as a single layer of epidermal progenitor cells. Their choice is to become a mature epidermal cell or...
How an ultra-sensitive on-off switch helps axolotls regrow limbs
by Sarah C. P. Williams - Phys.org It's one of the mysteries of nature: How does the axolotl, a small salamander, boast a superhero-like ability to regrow nearly any part of its body? For years, scientists have studied the amazing regenerative properties of the...
Like filling a pothole: Cell therapy for cartilage repair
By Susan Buckles - Mayo Clinic Growing up in the Netherlands, Daniel Saris, M.D., Ph.D., was exposed to the wonders of science at a young age. He listened to his father, a physicist, when he spoke at scientific conferences. His mother, an English teacher, encouraged...
New method an important step toward future 3D printing of human tissues
by University of Sydney A team of bioengineers and biomedical scientists from the University of Sydney and the Children's Medical Research Institute (CMRI) at Westmead have used 3D photolithographic printing to create a complex environment for assembling tissue that...
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