News and Opinions

By Inside Precision Medicine - The immunotherapy afamitresgene autoleucel (afami-cel) for the treatment of adults with the rare soft tissue cancer called synovial sarcoma was granted accelerated approval late last week by the U.S. Food and Drug Administration (FDA)....

By University of Barcelona - A study published in The EMBO Journal opens new perspectives to better understand how the molecular mechanisms involved in regenerative medicine work. The study focuses on tumour necrosis factor-α (TNF-α) and its receptors TNFR, molecules...

by Molly Coddington - Technology Networks - Like many young girls in elementary school, Victoria Gray wanted to be a cheerleader, until she was told by her doctor that this simply wouldn’t be possible; the exertion placed on her body by the training regimen could have...

by Marla Broadfoot, Ph.D. - Mayo Clinic - Pancreatic cancer is a formidable disease, often diagnosed too late for effective treatment. However, new research from Mayo Clinic represents a promising step toward identifying biological signals or biomarkers that may aid...

By Priya Baraniak - STAT News - Cutting-edge FDA-approved therapies made from human cells are now being used to treat cancer, diabetes, and other diseases. Currently, most approved cell-based therapies use an individual’s own cells, but the next generation of these...

By Medical Xpress News - In November 2021, Northwestern University researchers introduced an injectable new therapy, which harnessed fast-moving "dancing molecules," to repair tissues and reverse paralysis after severe spinal cord injuries. Now, the same research...

By Kennedy Ferruggia - Pharmacy Times - The FDA has granted regenerative medicine advanced therapy (RMAT) designation for AIC100 (Affylmmune Therapeutics), an ICAM-1 targeting and affinity-tuned LFA-1 binder chimeric antigen receptor (CAR) T-cell therapy product...

By Riken Research News - RIKEN researchers have uncovered how gradual changes in gene-expression patterns drive a cell-fate switch in neural stem cells (NSCs) in mice1. All the major neuronal types of cells in the central nervous system are created through the...

By University of Geneva - Acute myeloid leukaemia is one of the deadliest cancers. Leukaemic stem cells responsible for the disease are highly resistant to treatment. A team from the University of Geneva (UNIGE), University Hospital of Geneva (HUG), and Inserm has...

By NIH Research Matters - Variations in certain genes can modify the risk of developing Alzheimer’s disease (AD) and other types of dementia. Some of the best understood variants to date are in a gene called APOE. This gene plays a role in the transport of cholesterol...

By Josh Abbott - Bioprocess International - The International Space Station (ISS) presented a webinar Friday hosted by Patrick O’Neill, public affairs and outreach lead at the ISS. The webinar discussed the upcoming life science activities planned for the Northrop...

By Nature reviews Bioengineering The reprogramming of somatic cells into induced pluripotent stem cells using Yamanaka factors has revolutionized biomedical research. In the past few years, substantial advances have been made in differentiating them into a variety of...

By University of Virginia School of Engineering and Applied Science - Lab Manager - A research team at the University of Virginia School of Engineering and Applied Science has developed what it believes could be the template for the first building blocks for...

By Danielle Gerhard, PhD - The Scientist - ike the find-and-replace feature of a word processor, CRISPR-based engineering allows scientists to quickly and efficiently edit DNA sequences with base pair precision. Lauded as the great democratizer of gene editing, CRISPR...

By Susan Buckles - Mayo Clinic - Mayo Clinic envisions a day when regenerative science makes it possible to offer a total larynx transplant to anyone who needs one. The research team of David Lott, M.D., hopes to overcome a shortage of donor organs and minimize the...

By University of Glasgow - MedicalXpress - Scientists have created the first bioengineered bone marrow model that can support the type of human stem cells that are crucial for bone marrow transplants and in vitro study work. The research—published in Nature...

By Ernie Mundell - USNews - Women who've undergone stem cell treatments for blood cancers, or for illnesses such as sickle cell disease, can successfully bring a pregnancy to term, new research shows. The German findings run counter to the perceived wisdom on this...

By Genetic Engineering & Biotechnology News - Researchers at the University of California San Diego (UCSD) have found that two of the most frequently administered stem cell therapies, which are often used interchangeably, actually contain completely different types of...

By CincinnatiChildrens.org - Cincinnati Children’s Pluripotent Stem Cell Facility (PSCF) facilitates and supports research using human pluripotent stem cells (hPSCs). HPSCs are generated from a skin biopsy or blood sample that can be obtained from any patient and,...

By Adam Boros, PhD - Drug Discovery News - Genetically modified stem cells show promise in a targeted approach to taming inflammation in autoimmune diseases. Researchers developed an immunotherapy using chimeric antigen receptors and mesenchymal stromal cells, paving...