News and Opinions
World-first stem-cell treatment restores vision in people
By Smriti Mallapaty - Nature - The treatment, given to four people with damaged corneas, seems safe but needs to be tested in larger trials. Three people with severely impaired vision who received stem-cell transplants have experienced substantial improvements in...
‘Serial Killing’ Cell Therapy From Autolus Lands FDA Approval in Blood Cancer
By Frank Vinluan - MedCity News - Autolus Therapeutics’ Aucatzyl is now FDA approved for treating advanced cases of B-cell precursor acute lymphoblastic leukemia. While it goes after the same target as Gilead Sciences’ Tecartus, Autolus engineered its CAR T-therapy...
Mini-lungs could help fight flu & colds by tapping immunity
by Imma Perfetto - Cosmos - An Australian researcher has been awarded $60,000 to build more complex models of the human lung, with the hope to discover new therapies for respiratory diseases. Dr Rhiannon Werder, team leader at the Murdoch Children’s Research Institute...
Human stem cell-derived heart cells are safe in monkeys, could treat congenital heart disease
By By Jordana Lenon - University of Wisconsin-Madison - Heart muscle cells grown from stem cells show promise in monkeys with a heart problem that typically results from a heart defect sometimes present at birth in humans, according to new research from the University...
Nasal Spray Made From Stem Cell-Derived Vesicles Could Treat Alzheimer’s Disease
By Texas A&M College of Medicine News - A new therapy may delay Alzheimer’s disease progression by years, according to a study by researchers at Texas A&M University College of Medicine. Published in the Journal of Extracellular Vesicles, the research aims to...
New Stem Cell Data From Space
Arun Sharma, PhD By Cedars Sinai News - Cedars-Sinai investigators are one step closer to manufacturing stem cells in space, which could speed up the development of new medical therapies on Earth. The first published data from the experiments conducted on a private...
Stem cell therapy improves mental, physical health in relapsing-remitting MS
By Healio News - Top-line results of a phase 2 clinical trial for an adipose-derived autologous mesenchymal stem cell therapy to address mild to moderate relapsing-remitting MS found the treatment improved mental and physical health at 52 weeks. According to a press...
UNH Awarded $10M to Support Workforce Development in ReGen Valley Tech Hub Initiative
By UNH Manchester - The University of New Hampshire at Manchester has been awarded $10 million to lead workforce development efforts within the ReGen Valley Tech Hub, an initiative aimed at establishing Southern New Hampshire as a global leader in biofabrication....
Gene Editing Insights Progress Delivery Inside Body
By Inside Precision Medicine - U.S. researchers have shone further light into the precise way that CRISPR/Cas9 gene editing actually works and circumvents unintended off-target effects, which could lead to more accurate cellular therapies. The preclinical research,...
Lab-made muscle: New laser tech grows real human tissues to replace lab rats
by Mrigakshi Dixit - Interesting Engineering - Think of a future where injuries heal faster, diseases are cured more effectively, and lab-grown meat is a reality. This future is one step closer, thanks to the innovative work of Dr. Hao Liu from ETH Zurich. Liu uses...
Reversing lung scarring with a shot of stem cells
by Andrew Saintsing, PhD - Drug Discovery News - When the world ground to a halt in 2020, news outlets regularly featured stories about how COVID-19 wreaked havoc on patients’ lungs. In millions of cases, an initial cough developed into full-blown pneumonia, which...
UCLA researchers engineer experimental drug for preventing heart failure after heart attacks
By Ani Vahradyan - UCLA Broad Stem Cell Research Center - Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a first-of-its-kind experimental therapy that has the potential to enhance heart repair...
Do stem-cell transplants increase cancer risk? Long-lived recipients offer clues
By Smriti Mallapaty - Nature - Ever since the first blood-forming stem cells were successfully transplanted into people with blood cancers more than 50 years ago, researchers have wondered whether they developed cancer-causing mutations. A unique study1 on the...
Re-engineered, blue light-activated immune cells penetrate and kill solid tumors
by Pennsylvania State University - MedicalXpress - Immunotherapies that mobilize a patient's own immune system to fight cancer have become a treatment pillar. These therapies, including CAR T-cell therapy, have performed well in cancers like leukemias and lymphomas,...
Microenvironment-responsive nanomedicines: a promising direction for tissue regeneration
By BMC - Military Medical Research - Severe tissue defects present formidable challenges to human health, persisting as major contributors to mortality rates. The complex pathological microenvironment, particularly the disrupted immune landscape within these defects,...
Life Without Sickle Cell Beckons Boy Who Completed Gene Therapy
By Gina Kolata - New York Times - After 44 days, Kendric Cromer, 12, left the hospital. While his family feels fortunate that he was the first to receive a treatment, their difficult experiences hint at what others will be up against. Kendric Cromer, 12, left...
Neuroscientists discover a mechanism that can reactivate dormant neural stem cells
by Duke-NUS Medical School - MedicalXpress - An international team of neuroscientists, led by Duke-NUS Medical School, have uncovered a mechanism that controls the reactivation of neural stem cells, which are crucial for repairing and regenerating brain cells. The...
Human skin map gives ‘recipe’ to build skin and could help prevent scarring
by Wellcome Trust Sanger Institute - MedicalXpress - For the first time, researchers have created a single cell atlas of prenatal human skin to understand how skin forms, and what goes wrong in disease. Researchers from the Wellcome Sanger Institute, Newcastle...
Comparative analysis of single versus tandem autologous stem cell transplantation in patients with multiple myeloma in Korea: the KMM2102 study
By - Nature - Despite treatment advances, multiple myeloma (MM) remains incurable1. High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is considered the standard treatment for eligible patients2,3. Moreover, ASCT is reportedly effective and...
A new era of COVID-19 brings new outlooks for cellular therapy recipients
By A Donlan - Fred Hutch Cancer Center - During the COVID-19 pandemic, it quickly became clear that certain populations were particularly at risk for severe disease. Individuals undergoing hematopoietic cell transplants (HCT) or chimeric antigen receptor T-cell (CART)...
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