News and Opinions
After gene therapy exit, Pfizer locks in global license for Beam gene editing candidate
By Will Maddox - Fierce Biotech - After dumping its sole remaining gene therapy asset last year, Pfizer has decided to exercise its option for global rights to Beam Therapeutics’ liver-targeted gene editing candidate. The agreement, announced in Beam’s end-of-year...
Phase I/II study finds intravitreal CD34+ stem cells safe and feasible in CRVO
by Lynda Charters - Opthamology - A newly published study found that intravitreal injection of autologous CD34+ stem cells is well tolerated and feasible for treating loss of vision resulting from central retinal vein occlusion (CRVO), according to a press release...
New Bio-Implant for Spinal Cord Repair
By Neuroscience News.com - Spinal cord injuries have long been considered permanent because neurons in the central nervous system lack the natural ability to regrow. However, researchershave developed a novel, 3D-printed implant that could change that. The study...
Cracking a ‘holy grail’ challenge in cancer cell therapy
By Karen Guzman - Yale News - Yale scientists have engineered natural killer cells that eliminate solid tumors in mouse models. The study may lead to a simpler, “off the shelf” immunotherapy for hard-to-treat cancers. Since scientists first discovered that human...
Stem cells provide a potent treatment for frailty
By Edward Chen - Nature - Elderly people with frailty, which affects up to one-quarter of over-50s, increased their endurance after a single dose of stem cells. A single dose of stem cells can help older people with frailty to build up their endurance, a study finds1....
New Stem Cell Treatment Sparks Hope for Parkinson’s Disease
By Keck Medicine of US - SciTechDaily - A pioneering clinical trial is exploring whether lab-engineered stem cells can restore dopamine production in people with Parkinson’s disease. In Parkinson’s disease, the problem starts deep in the brain, where a small group of...
Paralysis Treatment Heals Lab-Grown Human Spinal Cord Organoids
By Amanda Morris - Northwestern Medicine - New therapy triggers neurite growth, reduces scarring in injured organoids Northwestern University scientists have developed the most advanced organoid model for human spinal cord injury to date. In a new study published in...
Gene editing that spreads within the body could cure more diseases
By Michael Le Page - NewScientist - The idea of self-amplifying gene editing is to get cells to pass on packages of CRISPR machinery to their neighbours, boosting the effect Imagine if, instead of delivering a leaflet individually to each home, a postal worker just...
Smart biomaterials for skeletal aging repair and regeneration
By Nature | Bone Research - Skeletal aging associated with diverse age-related disorders is increasing due to unhealthy diets, stressful lifestyles, and rapid aging. Repair and regeneration of aging skeletons are a global issue. Despite the self-healing ability of...
Stem cell therapy ‘reverses’ type 2 diabetes in world-first case in China
By Smarica Pant - India Today - hinese researchers say a patient with Type 2 diabetes is now insulin-free after stem cell treatment. Experts call it promising but caution that more large-scale trials are needed. In what is being described as a major medical milestone,...
AI uncovers the hidden genetic control centers driving Alzheimer’s
By University of California - Irvine - ScienceDaily - Scientists have created the most detailed maps yet of how genes control one another inside the brains of people with Alzheimer’s disease. Using a powerful new AI-based system called SIGNET, the team uncovered...
Humans Have a Third Set of Teeth. New Medicine May Help Them Grow.
By Tim Newcomb - Popular Mechanics - They could be ready by 2030. A sliver of what makes sharks so intriguing comes with their ability to regrow teeth. And while a group of Japanese researchers aren’t claiming that we should be trying to be the most shark-like...
Toward Engineering a Human Kidney Collecting-Duct System
By Benjamin Boettner - Harvard School of Engineering - The human kidney filters about a cup of blood every minute, removing waste, excess fluid and toxins from it, while also regulating blood pressure, balancing important electrolytes, activating Vitamin D, and...
New 3D brain organoids reveal how glioblastoma evades treatment
By Drug Target Review - Researchers have developed 3D human brain organoids that reveal how glioblastoma interacts with brain and immune cells, discovering hidden drivers of tumour invasion. UCLA scientists have created advanced miniature 3D tumour organoid models...
Alzheimer’s scrambles memories while the brain rests
By ScienceDaily - New findings reveal a subtle but powerful breakdown that may help explain early memory loss in Alzheimer’s. When the brain rests, it usually replays recent experiences to strengthen memory. Scientists found that in Alzheimer’s-like mice, this replay...
CRISPR grapefruit without the bitterness are now in development
By NewScientist - Gene-editing citrus fruits to make them less bitter could not only encourage more people to eat them, it might also help save the industry from a devastating plague If you never eat grapefruit because you find them far too bitter, CRISPR varieties...
Combining Biology and AI To Advance Cell Therapy
By Suzanne Day - Harvard Medical School - The future of federally funded research at Harvard Medical School — supported by taxpayers and done in service to humanity — remains uncertain. Learn more. One of the most enduring goals in regenerative medicine is deceptively...
Rethinking longevity: Genes account for 50% of human lifespan variation, study suggests
by Weizmann Institute of Science - MedicalXpress - What determines how long we live—and to what extent is our lifespan shaped by our genes? Surprisingly, for decades, scientists believed that the heritability of human lifespan was relatively low compared to other...
Podcast – SENESCENT CELLS – An Important Target for Diseases of Aging
WATCH: This episode explores cellular senescence, its biological roles, implications for aging and age-related diseases, and emerging therapeutic strategies, with insights from Dr. Lorna Harries, a professor of molecular genetics and founder of the biotech company...
Mum hails cord blood donation after life-saving transplant
by Mariam Issimdar - BBC - A mother who donated umbilical cord blood after giving birth has described how her own daughter's life was saved by a similar donation just a few years later. Natasha Kirkpatrick donated her daughter Ellaria's cord blood when she was born in...
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