News and Opinions
Bioinformatics Uncovers Regenerative Therapy for Spinal Cord Injury
Miles Martin - UC San Diego Today - Spinal cord injury (SCI) remains a major unmet medical challenge, often resulting in permanent paralysis and disability with no effective treatments. Now, researchers at University of California San Diego School of Medicine have...
Scientists Create Early Human Embryos From Skin Cells And Sperm
By StudyFinds Analysis - Researchers have created human embryos by taking nuclei from ordinary skin cells, placing them into donated eggs, and fertilizing them with sperm. The work is a laboratory demonstration that shows what might eventually be possible for people...
Parkinson’s treatment tested at UW showing promise in first clinical trial
By Chris Barncard - University of Wisconsin News - Parkinson’s patients are receiving a new investigational treatment after a successful study at the University of Wisconsin–Madison helped demonstrate the cell therapy’s safety in non-human primates and refine the...
New UCLA drug could restore heart and organ function
By Drug Target Review - UCLA researchers have developed a monoclonal antibody, AD-NP1, that blocks ENPP1 to enhance heart repair and reduce scar tissue. Injuries like cuts to the skin tend to heal naturally, but damage to internal organs like the heart or kidneys...
Long-Term Growth Hormone Therapy Boosts Pediatric Stem Cells
by Bioenginee.org - In a groundbreaking study published in Scientific Reports, researchers have unveiled significant findings surrounding the long-term effects of growth hormone therapy in pediatric patients suffering from growth hormone deficiency. This research is...
Embryo-Like ‘Blood Factories’ Could One Day Supplement Donations
By Jess Cockerill - Science Alert - Clusters of cells grown in the lab have been encouraged to produce human blood stem cells in a discovery that could one day supplement donations to people with blood disorders like leukemia and lymphoma. The University of...
High-throughput 3D engineered paediatric tumour models for precision medicine
By Molecular Systems Biology - Abstract Precision medicine for paediatric and adult cancers that incorporates drug sensitivity profiling can identify effective therapies for individual patients. However, obtaining adequate biopsy samples for high-throughput (HTP)...
New CAR T therapy targets solid tumours safely and effectively
By Drug Target Review - USC researchers have engineered CAR T cells to deliver a dual protein therapy that targets solid tumours – offering hope for cancers previously resistant to treatment. Chimeric antigen receptor (CAR) T-cell therapy, which uses a patient’s own...
Takeda Exits Cell Therapy Amid Strategic Pivot, Dealing Blow to Once Promising Modality
by Tristan Manalac - BioSpace - Takeda is looking to offload its cell therapy platform and preclinical assets to a yet-unidentified external partner. 137 employees will be let go as part of the move. Takeda will no longer invest in cell therapies moving forward as the...
New Tool Identifies Proteins That Control Gene Activity
by Weill Cornell Medicine - he SCOPE system can capture proteins binding to regions of DNA that control gene expression. The illustration depicts part of the process where a small guide RNA delivers a protein bearing a special amino acid to the desired region....
This “chaos enzyme” may hold the key to stopping cancer spread
By Science Daily - A Weill Cornell Medicine team has found that triple-negative breast cancer depends on the enzyme EZH2 to spread. By silencing key genes, EZH2 drives chaotic cell divisions and fuels metastasis. Blocking EZH2 restored stability and prevented cancer...
Adult Stem Cells Improve Vision in Patients With Macular Degeneration
by Technology Networks - In a first-in-human Phase 1/2a clinical trial, adult stem cells improved vision in patients with macular degeneration. In the United States, age-related macular degeneration is a leading cause of irreversible vision loss in people who are 60...
Stem cells may offer new hope for end-stage kidney disease treatment
By Alison Satake - Mayo Clinic - More than 4 million people worldwide have end-stage kidney disease that requires hemodialysis, a treatment in which a machine filters waste from the blood. Hemodialysis is a precursor to kidney transplant. To prepare for it, patients...
Distal lung organoids derived from adult stem cells as novel tools in deciphering mechanisms of lung regeneration, infection, and cancer
By Stem Cells Translational Medicine - Introduction While lung research has made great strides in understanding lung physiology, lung pathology still presents a major burden to patients and healthcare systems globally. To develop new effective therapeutics to improve...
ISSCR Unveils Roadmap for Advancing Pluripotent Stem Cell-Derived Therapies
by Bioengineer.org - The International Society for Stem Cell Research (ISSCR) has unveiled an innovative and comprehensive resource entitled Best Practices for the Development of Pluripotent Stem Cell-Derived Cellular Therapies, marking a pivotal advancement in the...
This medical startup uses LLMs to run appointments and make diagnoses
By Grace Huckins - MIT Technology Review - Imagine this: You’ve been feeling unwell, so you call up your doctor’s office to make an appointment. To your surprise, they schedule you in for the next day. At the appointment, you aren’t rushed through describing your...
Lab-grown kidneys show real function in new stem cell study
By Drug Target Review - A USC Stem Cell-led research team have made a big breakthrough in their efforts to build mouse and human synthetic kidneys. In a new paper published in Cell Stem Cell, the scientists describe generating more mature and complex lab-grown...
New gene therapy slows progression of Huntington’s disease by 75%
By Sky News - It is likely to be the first licensed treatment to slow Huntington's, and that "changes everything", says lead investigator Professor Ed Wild. Known as AMT-130, it is delivered via brain surgery, and a single dose is expected to last someone's whole...
AI-designed viruses are here and already killing bacteria
By MIT Technology Review - Artificial intelligence can draw cat pictures and write emails. Now the same technology can compose a working genome. A research team in California says it used AI to propose new genetic codes for viruses—and managed to get several of these...
Junk DNA” Found to Sense Its Environment, May Hold the Key to Disease Treatment
By Bernadette Gillis - Duke university School of Medicine - A new study from Duke University School of Medicine has uncovered a surprising role for what was once considered “junk DNA.” Researchers found that these overlooked parts of our genetic code help stem cells...
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