News and Opinions
How genetically modified stem cells could repair the brain after a stroke
By Mental Health - Every year, millions of lives are suddenly, swiftly transformed by a stroke, which occurs when a blood vessel travelling towards the brain becomes obstructed, causing neurons to die off. Strokes are among the leading causes of disability in adults,...
Stem cell engineering breakthrough paves way for next-generation living drugs
By University of British Columbia - For the first time, researchers at UBC have demonstrated how to reliably produce an important type of human immune cell — known as helper T cells — from stem cells in a controlled laboratory setting. The findings, published today in...
Stanford Medicine study shows why mRNA COVID-19 vaccine can cause myocarditis
By Bruce Goldman - Stanford Medicine - Stanford Medicine investigators have unearthed the biological process by which mRNA-based vaccines for COVID-19 can cause heart damage in some young men and adolescents — and they’ve shown a possible route to reducing its...
This CRISPR breakthrough turns genes on without cutting DNA
by University of New South Wales - Science Daily - A new CRISPR breakthrough shows scientists can turn genes back on without cutting DNA, by removing chemical tags that act like molecular anchors. The work confirms these tags actively silence genes, settling a...
The Quest to Cure Myeloma: Mission Accomplished?
by Charles Bankhead - MedPageToday - Long-term survival in the CARTITUDE-1 trial showed that almost half of patients remained, alive with a median overall survival (OS) of 60.7 months. Almost three-fourths of the survivors remained progression free, and more than a...
Successful CAR T Treatment for Large B Cell Lymphoma May Depend on Circadian Rhythms
By Julie Grisham - Memorial Sloan Kettering Cancer Center - When it comes to giving immunotherapy to people with the most common form of lymphoma, the time of day may make a difference, according to new research from Memorial Sloan Kettering Cancer Center (MSK)....
Scientists Unveil Breakthrough Method to Mass-Produce Cancer-Fighting Natural Killer Cells
By Chinese Academy of Sciences - SciTechDaily - A new method for engineering natural killer cells could make cancer immunotherapy more efficient, scalable, and affordable, potentially reshaping how these treatments are produced. Chinese scientists have reported a new...
Fatal Complication of Stem Cell Transplants Gets Its First FDA-Approved Therapy
By Frank Vinluan - MedCity News - A rare but severe stem cell transplant complication that often becomes fatal now has its first FDA-approved treatment, a therapy developed by biotechnology company Omeros. Omeros’s complement system drug Yartemlea is now FDA approved...
Top FDA Gene and Cell Therapy News: 2025 Year-End Recap
By Matt Hoffman - CGTlive - As 2025 comes to a close, CGTLive has looked back on some of the most-read and most impactful FDA regulatory decisions and news in the cell and gene therapy space. These approvals and regulatory actions marked major progress for patients...
Engineered Dendritic Cells Harness Tumor EVs to Boost Cancer Immunotherapy
By Genetic Engineering adn Biotechnology News - Cancer immunotherapy transforms a patient’s immune cells into a “search‑and‑destroy” force against tumors. But many cancers learn to camouflage themselves from dendritic cells—the immune system’s scouts—making them...
Melanoma cancer cells secrete extracellular vesicles to paralyze immune cells
by Tel-Aviv University - MedXpress - A new international study led by Prof. Carmit Levy of the Department of Human Genetics and Biochemistry at the Gray Faculty of Medical & Health Sciences at Tel Aviv University finds that melanoma cancer cells paralyze immune...
How Our Own Cells Could Implant The Next Generation Of Nonsurgical Brain Microchips
By William A. Haseltine, - Forbes - Treating brain diseases is extraordinarily challenging, because drugs often work poorly and implants require risky surgery that can jeopardize critical brain functions. A group at MIT has sought a different approach, using the...
MIT Scientists Have Discovered a Way To Rejuvenate the Immune System
By Anne Trafton, Massachusetts Institute of Technology - ScitTechDaily - As the immune system weakens with age, researchers have found a way to temporarily boost its function by reprogramming liver cells to support T-cell development. As people get older, the immune...
New method preserves iPS cells for regenerative medicine
By Drug Target Review - Kobe University researchers have developed a new way of freeze induced pluripotent stem cells (iPS cells) directly in their culture dishes without losing viability or pluripotency. Researchers at Kobe University have developed a novel method...
The 98% mystery: Scientists just cracked the code on “junk DNA” linked to Alzheimer’s
by Science Daily - Researchers have revealed that so-called “junk DNA” contains powerful switches that help control brain cells linked to Alzheimer’s disease. By experimentally testing nearly 1,000 DNA switches in human astrocytes, scientists identified around 150...
Lab-Grown Brain Tissue Finally Wires Itself Thanks to Crystal-Loaded Microgels
by ScienceBlog - Researchers at the University of Illinois Urbana-Champaign have engineered a solution using tiny microgels packed with antioxidant crystals. Published in Advanced Functional Materials, their work demonstrates how a single dose of these protective...
Interviews of 2025: The Big Issues
By Danny Sullivan - Longevity.Technology - Healthspan as a universal right, the need for new regulation, the age of mitochondrial therapies and 7 shifts to accelerate longevity. As we reflect on some of the interviews we’ve conducted over the past 12 months, it’s...
Case Study: Patient Remains Disease Free Five Years After Allogenic CAR T-Cell Therapy
By Cleveland Clinic - Patient with quadruple refractory multiple myeloma achieves complete response with cell therapy A Cleveland Clinic patient participated in a clinical trial of allogenic CAR T-cell therapy to treat highly resistant multiple myeloma and achieved a...
To Bring Cell Culture into the Future, Consider Microenvironments
by James Lim, PhD - The Scientist - Let’s face it: Nobody pursues a career in science for the joy of culturing cells. But this thankless and time-intensive task is the backbone of biological research. When it’s done extremely well, the results generated from...
UC Irvine receives $12 million to test novel stem cell therapy for Huntington’s disease
By UCI Health News - CIRM award will support first-of-its-kind clinical trial in humans This award will support a first-in-human safety and tolerability study of an embryonic stem cell-derived neural stem cell product for Huntington’s disease, a milestone for patients...
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