News and Opinions
Stanford makes stem cell transplants safer without chemo
By Stanford Medicine - ScienceDaiiy - A Stanford-led team has replaced toxic pre-transplant chemotherapy with a targeted antibody, allowing children with Fanconi anemia to receive stem cell transplants safely. The antibody, briquilimab, removes diseased stem cells...
Anti-fibrotic effect of human amniotic fluid stem cells in biliary epithelial-mesenchymal transition of liver ductal organoid
By Stem Cells Translational Medicine - Abstract Purpose In biliary atresia (BA), it has been demonstrated that biliary epithelial-mesenchymal transition (EMT) of reactive ductular cells is associated with liver fibrosis. This study aimed to develop an ex vivo biliary...
Lab-grown liver model offers a platform to study fibrosis and regeneration
by Institute of Science Tokyo - MedicalXpress - As chronic liver disease becomes more widespread, researchers at Science Tokyo have developed a lab-grown organoid that replicates a regenerating liver, offering new hope for future treatments. The model recreates...
How A New AI Model Exposes A Hidden Weakness In Cancer Cells
By William A. Haseltine - Forbes - New research from DeepMind and Yale University has created AI that now generates biological hypotheses that can lead to new medical discoveries. The collaboration between recently produced C2S-Scale 27B, a powerful AI model trained...
Scientists 3D print muscle tissue in zero gravity to study diseases beyond Earth
By Aamir Khollam - Interesting Engineering - In a leap that could reshape how scientists study the human body in space, researchers at ETH Zurich have successfully 3D printed muscle tissue in conditions mimicking weightlessness. The achievement brings scientists...
Stroke Damage Reversed As Stem Cells Regrow the Brain
By University of Zurich - SciTechDaily - Stem cell therapy reversed stroke damage in mice, regenerating neurons and restoring movement. The findings bring scientists closer to human treatments that could one day transform recovery after brain injury. Breakthrough in...
Microencapsulated 3D culture of human umbilical cord-derived mesenchymal stem cells enhances their therapeutic effect on intrauterine adhesion Open Access
By Stem Cells Translational Medicine - Abstract Therapeutic application of mesenchymal stem cells is emerging as a potential strategy for the management of intrauterine adhesion (IUA). However, conventional 2D cultures often face issues such as insufficient cell...
‘My hero’: 9-year-old boy helps father fight cancer with stem cell donation
By KCAL/KCBS via CNN Newsource Watch Video - A 9-year-old California boy is being called a hero after he saved his father’s life with a stem cell donation. Nick Mondek, a 45-year-old father of two, was facing a second battle with leukemia in April when his...
CAR NK cell therapy clinical trial puts follicular lymphoma survivor into remission
By Cynthia DeMarco - MD Anderson Cancer Center - When JC Cox was diagnosed with a type of non-Hodgkin lymphoma called follicular lymphoma in 2006, the now-retired HVAC technician sought treatment close to his home in Dallas. But several rounds of strong chemotherapy...
Stem cell therapy linked to lower risk of heart failure after a heart attack
By BMJGroup - Technique may be a valuable add-on procedure for patients with weak heart function after a heart attack, say researchers Patients with weak heart function who receive stem cell therapy shortly after a heart attack are at lower risk of developing heart...
Bioinformatics Uncovers Regenerative Therapy for Spinal Cord Injury
Miles Martin - UC San Diego Today - Spinal cord injury (SCI) remains a major unmet medical challenge, often resulting in permanent paralysis and disability with no effective treatments. Now, researchers at University of California San Diego School of Medicine have...
Scientists Create Early Human Embryos From Skin Cells And Sperm
By StudyFinds Analysis - Researchers have created human embryos by taking nuclei from ordinary skin cells, placing them into donated eggs, and fertilizing them with sperm. The work is a laboratory demonstration that shows what might eventually be possible for people...
Parkinson’s treatment tested at UW showing promise in first clinical trial
By Chris Barncard - University of Wisconsin News - Parkinson’s patients are receiving a new investigational treatment after a successful study at the University of Wisconsin–Madison helped demonstrate the cell therapy’s safety in non-human primates and refine the...
New UCLA drug could restore heart and organ function
By Drug Target Review - UCLA researchers have developed a monoclonal antibody, AD-NP1, that blocks ENPP1 to enhance heart repair and reduce scar tissue. Injuries like cuts to the skin tend to heal naturally, but damage to internal organs like the heart or kidneys...
Long-Term Growth Hormone Therapy Boosts Pediatric Stem Cells
by Bioenginee.org - In a groundbreaking study published in Scientific Reports, researchers have unveiled significant findings surrounding the long-term effects of growth hormone therapy in pediatric patients suffering from growth hormone deficiency. This research is...
Embryo-Like ‘Blood Factories’ Could One Day Supplement Donations
By Jess Cockerill - Science Alert - Clusters of cells grown in the lab have been encouraged to produce human blood stem cells in a discovery that could one day supplement donations to people with blood disorders like leukemia and lymphoma. The University of...
High-throughput 3D engineered paediatric tumour models for precision medicine
By Molecular Systems Biology - Abstract Precision medicine for paediatric and adult cancers that incorporates drug sensitivity profiling can identify effective therapies for individual patients. However, obtaining adequate biopsy samples for high-throughput (HTP)...
New CAR T therapy targets solid tumours safely and effectively
By Drug Target Review - USC researchers have engineered CAR T cells to deliver a dual protein therapy that targets solid tumours – offering hope for cancers previously resistant to treatment. Chimeric antigen receptor (CAR) T-cell therapy, which uses a patient’s own...
Takeda Exits Cell Therapy Amid Strategic Pivot, Dealing Blow to Once Promising Modality
by Tristan Manalac - BioSpace - Takeda is looking to offload its cell therapy platform and preclinical assets to a yet-unidentified external partner. 137 employees will be let go as part of the move. Takeda will no longer invest in cell therapies moving forward as the...
New Tool Identifies Proteins That Control Gene Activity
by Weill Cornell Medicine - he SCOPE system can capture proteins binding to regions of DNA that control gene expression. The illustration depicts part of the process where a small guide RNA delivers a protein bearing a special amino acid to the desired region....
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