News and Opinions
Researchers Uncover New Strategy To Boost Stem Cell Transplant Harvesting
by Blake Forman - Technology Networks - Impairing a particular stem cell surface protein could improve mobilization and availability for transplantation. Stem cell transplants have become widely used to treat diseases such as cancer, blood disorders and autoimmune...
Fasting’s effects on stem cells linked to increased cancer risk
By Michael Franco - New Atlas - A new study from MIT has revealed the exact mechanism by which fasting causes intestinal stem cells to regenerate, which is one of the practice's benefits. However, the study also showed a downside that needs to be considered when...
Tiny Test Tubes Sort Stem Cells for Improved Therapy
by Rebecca Roberts, PhD - The Scientist - With the power of self-renewal and multipotency, mesenchymal stem cells (MSCs) offer the possibility of regenerative treatment for a variety of medical conditions, including spinal cord injury and damage following a heart...
Study reveals the benefits and downside of fasting
by Anne Trafton - MIT News - Fasting helps intestinal stem cells regenerate and heal injuries but also leads to a higher risk of cancer in mice, MIT researchers report. Low-calorie diets and intermittent fasting have been shown to have numerous health benefits: They...
Targeted Cancer Cell Therapy May Slow Endometrial Cancer
By University of Missouri School of Medicine - There may be a way to slow the growth of endometrial cancer through targeted cancer cell therapy, according to new research from the University of Missouri School of Medicine. This year, around 65,000 women are expected...
Automation and Standardization Will Cut Cell and Gene Therapy Production Costs
By Gareth John MacDonald - Genetic Engineering & Biotechnology News - A new generation of automated technologies in cell and gene therapy manufacturing systems will help more people benefit according to research identifying high production cost as the main impediment...
Macrophage cell therapy: a new hope for chronic liver disease patients
By Cliff Brass - Drug Target Review - Resolution Therapeutics is pioneering a novel approach to the treatment of chronic liver disease – by engineering the patient’s own macrophages to include regenerative properties. Cliff Brass, Chief Medical Officer at Resolution...
Stem Cell Transplant Patient and Donor Form Forever Bond
By Abe Rosenberg - City of Hope - When Camila Quino's acute lymphoblastic leukemia returned for a third time, a stem cell transplant was the 24-year-old's last option. Finding a new best friend wasn't a part of the plan Back in 2022, when they were total strangers,...
Going slow is better for fast cycling: Study reveals unique replication fork behavior in pluripotent stem cells
by National Institutes of Natural Sciences - Phys.org - Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic replication stress....
Diabetes took over her life, until a stem cell therapy freed her
By Carolyn Y. Johnson - The Washington Post - For years, Amanda Smith and her husband were jolted awake at night by a buzz-buzz-beep — an alarm warning that her blood sugar was too high or too low. She would reach for juice boxes stored in her nightstand or fiddle...
Brand New Publication: Nucleic Acid Therapeutics
By Mary Ann Liebert, Inc Publishers - This cover illustrates the original research report submitted by Anastasia Khvorova of the RNA Therapeutics Institute, University of Massachusetts Chan Medical School. This gorgeous image depicts the observation that nuclear...
Understanding CAR-T cell therapy for cancer: A promising, less arduous cancer treatment
By Sara Youngblood Gregory - Mayo Clinic - For many scientists and doctors, immunotherapy that uses someone’s own immune system to target and attack cancer cells is the next and best frontier of cancer treatment. Over the last decade, immunotherapy-focused research...
Discoveries from human stem cell research in space that are relevant to advancing cellular therapies on Earth
By Fay Ghani, Abba C. Zubair - Nature - Stem cell research performed in space has provided fundamental insights into stem cell properties and behavior in microgravity including cell proliferation, differentiation, and regeneration capabilities. However, there is...
Zebrafish use surprising strategy to regrow spinal cord
by Julia Evangelou Strait - Washington University College of Medicine - Detailed blueprint of nerve cells’ dramatic changes could help identify ways to heal spinal cord damage. Zebrafish are members of a rarefied group of vertebrates capable of fully healing a severed...
New way to extend ‘shelf life’ of blood stem cells will improve gene therapy
By University of Cambridge - Researchers have discovered a way to extend the shelf life of blood stem cells outside the body for use in gene therapy, providing patients with better options and improving their outcomes. We were able to identify a key molecular...
Understanding the Risk of Second Cancers After CAR T-Cell Therapy
By The National Cancer Institute - In November 2023, the Food and Drug Administration announced that it was investigating more than 20 instances of second cancers—specifically, T-cell lymphomas—in people who had been treated with CAR T-cell therapies. In several...
Astrocytes Are a Key Player in the Awakeneing of Dormant Neural Stem Cells
By Technology Networks - Research offers new hope for treating neurodevelopmental disorders by activating dormant neural stem cells. Scientists from Duke-NUS Medical School and the Mechanobiology Institute (MBI) at the National University of Singapore (NUS) have...
UofL cardiologist leading clinical trial for high potential new therapy for heart failure
By University of Louisville School of Medicine - A new stem cell therapy for heart failure is being tested in patients at the University of Louisville and UofL Health. The trial is the first in the U.S. to test umbilical cord-derived stem cells in patients for heart...
UofL cardiologist leading clinical trial for high potential new therapy for heart failure
By University of Louisville School of Medicine - A new stem cell therapy for heart failure is being tested in patients at the University of Louisville and UofL Health. The trial is the first in the U.S. to test umbilical cord-derived stem cells in patients for heart...
Next-generation CRISPR-based gene-editing therapies tested in clinical trials
By Natalie Healey - Nature Medicine Going from the laboratory to an approved therapy in 11 years is no mean feat. That is the story of the world’s first approved CRISPR–Cas9 therapy, greenlit by the US Food and Drug Administration in December 2023....
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