News and Opinions
The future of replacement organs is (quite possibly) here: Robust human intestinal organoids created in a lab
by Tokyo Medical and Dental University - Phys.Org Growing miniature organ-like tissues in the lab is already within our reach. Now, researchers from Japan have developed a new approach that enables intestinal mini-organs to be grown more easily and efficiently in the...
Genetic cause of ALS and dementia repaired by RNA-targeting strategy developed at UF Scripps
By: Stacey DeLoye UFHealth News Scientists at UF Scripps Biomedical Research have developed a potential medicine for a leading cause of ALS and dementia that works by eliminating disease-causing segments of RNA. The compound restored the health of neurons in the lab...
Highly Mature Neurons Created
By Technology Netowrks Northwestern University-led researchers have created the first highly mature neurons from human induced pluripotent stem cells (iPSCs), a feat that opens new opportunities for medical research and potential transplantation therapies for...
JPM23’s Medtech Tidbits: Reporting from San Francisco
By Andrea Park, Conor Hale - Fierce Biotech SAN FRANCISCO—After years of stops, starts and stops again, the J.P. Morgan Healthcare Conference has returned to the city by the bay in full form. Below we've compiled the biggest medtech news so far, bite-sized—from both...
Scientists Identify How a Biological Pathway Leads Stem Cells to Die or Regenerate
Manipulating Cell Signaling Can Possibly Ensure the Body Has a Healthy Amount of Cells By Stephanie Cajigal - Cedars Sinai A new study led by Cedars-Sinai and the University of California, San Francisco (UCSF), has determined that altering a cellular process can lead...
Genetics, Alzheimer’s And AI — Why 2023 Could Be The Year For Biotech Stocks
By Allison Gatlin - Investors.com If there's one overarching theme that investors in biotech stocks should pay attention to in 2023, it's "genetic medicine, genetic medicine, genetic medicine," says Christopher Anzalone. Anzalone is biased, of course. He's the chief...
O.K. Corral: FDA sets stage to appeal California Stem Cell Treatment Center decision
Michael Druckman, Meredith Manning, and Ashley Grey - Hogan Lovells Last year, a federal court in California ruled against the U.S. Food and Drug Administration (FDA) in a matter where the government alleged that a stem cell clinic’s products should be regulated as...
Teaming Up Two Biotech Winners to Fight Cancer: CRISPR and CAR T
by William A. Haseltine - Forbes Here we describe early clinical trial results on combination CRISPR and CAR T therapy, a sequel to an earlier, introductory piece. Other alternative CAR T designs include mRNA vectors to create temporary CAR T cells and the use of...
The future of replacement organs is (quite possibly) here: Robust human intestinal organoids created in a lab
by Tokyo Medical and Dental University - Phys.org Growing miniature organ-like tissues in the lab is already within our reach. Now, researchers from Japan have developed a new approach that enables intestinal mini-organs to be grown more easily and efficiently in the...
MS patients could be offered stem cell transplants as a first-line treatment in new world-first trial
A world-first trial is investigating if stem cell transplantation could be used in patients with aggressive multiple sclerosis (MS) as a first-line treatment. By University of Sheffield The study launched by the University of Sheffield and Sheffield Teaching Hospitals...
Scientists Receive $4.8M to Pursue Gene Therapy for ‘Incurable’ Disease
CIRM grant will fund novel gene therapy aiming for one-time, lifelong treatment of Friedreich’s ataxia, a progressive neuromuscular disorder; second CIRM grant will advance efforts to leverage UC San Diego research on another rare disease By Scott LaFee - UC San Diego...
Scientists identify neurons that restore walking after paralysis
By EPFL News A new study by scientists at the .NeuroRestore research center has identified the type of neuron that is activated and remodeled by spinal cord stimulation, allowing patients to stand up, walk and rebuild their muscles – thus improving their quality of...
A different kind of cell signal: New method enables clear, precise imaging of human cells
Researchers at the Beckman Institute for Advanced Science and Technology developed a new method to ‘see’ the fine structure and chemical composition of a human cell with unmatched clarity and precision. By Jenna Kurtzweil - University of Illinois Beckman Institute...
FDA no longer needs to require animal tests before human drug trials
By Meredith Wadman - Science New law welcomed by animal welfare groups, but others say change won’t happen fast New medicines need not be tested in animals to receive U.S. Food and Drug Administration (FDA) approval, according to legislation signed by President Joe...
Phase 3 Clinical Trial: Brain Cancer Vaccine Shows Promising Results
by Press Office - King’s College London - neurosciencenews.com Summary: Results of a phase three clinical trial of a novel brain cancer vaccine, DCVax-L, that uses a patient’s stem cells to target cancer cells extended survival by many months to years for glioblastoma...
Cancer stem cells are fueled through dialogue with their environments
By Elaine Fuchs - The Rockefeller University Image Caption: TGF beta signaling (red) is one way that the environment causes cancer stem cells at the stroma-tumor border (green) to become invasive. Living cells are dyed blue. Credit: Shaopeng Yuan What drives tumor...
Stem Cell Transplant May Be Viable Treatment for Patients With HIV, Leukemia, Says Dr Jana Dickter
By Hayden E. Klein and Skylar Jeremias - AJMC Jana K. Dickter, MD, associate clinical professor, Division of Infectious Diseases, City of Hope, discusses a patient's experience being the oldest person to successfully undergo a stem cell transplant while living with...
CRISPR’s ‘ancestry problem’ misses cancer targets in those of African descent
Reference genomes used to direct the gene editor fail to account for human diversity By Jocelyn Kaiser - Science The 10-year-old gene-editing tool known as CRISPR is indispensable for engineering plants, tailoring lab animals, and probing basic biology. But there’s a...
Fetal Therapy Offers Hope for Patients with Rare Genetic Disorders
Toddler Thrives with Same Disease That Ended Siblings’ Lives By University of California San Francisco When Zahid and Sobia Bashir discovered their fetus had the same genetic disease that took the lives of two of their young children, they didn’t hesitate to sign up...
Researchers Find Treatment Options for Patients Whose Blood Cancer Relapses After CAR-T
Addresses major gap in effectiveness of immunotherapy Mount Sinai Press Release New York, NY - Mount Sinai and Memorial Sloan Kettering Cancer Center (MSK) researchers have identified therapies that can help patients with the blood cancer multiple myeloma who try an...
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