News and Opinions
Scientists identify neurons that restore walking after paralysis
By EPFL News A new study by scientists at the .NeuroRestore research center has identified the type of neuron that is activated and remodeled by spinal cord stimulation, allowing patients to stand up, walk and rebuild their muscles – thus improving their quality of...
A different kind of cell signal: New method enables clear, precise imaging of human cells
Researchers at the Beckman Institute for Advanced Science and Technology developed a new method to ‘see’ the fine structure and chemical composition of a human cell with unmatched clarity and precision. By Jenna Kurtzweil - University of Illinois Beckman Institute...
FDA no longer needs to require animal tests before human drug trials
By Meredith Wadman - Science New law welcomed by animal welfare groups, but others say change won’t happen fast New medicines need not be tested in animals to receive U.S. Food and Drug Administration (FDA) approval, according to legislation signed by President Joe...
Phase 3 Clinical Trial: Brain Cancer Vaccine Shows Promising Results
by Press Office - King’s College London - neurosciencenews.com Summary: Results of a phase three clinical trial of a novel brain cancer vaccine, DCVax-L, that uses a patient’s stem cells to target cancer cells extended survival by many months to years for glioblastoma...
Cancer stem cells are fueled through dialogue with their environments
By Elaine Fuchs - The Rockefeller University Image Caption: TGF beta signaling (red) is one way that the environment causes cancer stem cells at the stroma-tumor border (green) to become invasive. Living cells are dyed blue. Credit: Shaopeng Yuan What drives tumor...
Stem Cell Transplant May Be Viable Treatment for Patients With HIV, Leukemia, Says Dr Jana Dickter
By Hayden E. Klein and Skylar Jeremias - AJMC Jana K. Dickter, MD, associate clinical professor, Division of Infectious Diseases, City of Hope, discusses a patient's experience being the oldest person to successfully undergo a stem cell transplant while living with...
CRISPR’s ‘ancestry problem’ misses cancer targets in those of African descent
Reference genomes used to direct the gene editor fail to account for human diversity By Jocelyn Kaiser - Science The 10-year-old gene-editing tool known as CRISPR is indispensable for engineering plants, tailoring lab animals, and probing basic biology. But there’s a...
Fetal Therapy Offers Hope for Patients with Rare Genetic Disorders
Toddler Thrives with Same Disease That Ended Siblings’ Lives By University of California San Francisco When Zahid and Sobia Bashir discovered their fetus had the same genetic disease that took the lives of two of their young children, they didn’t hesitate to sign up...
Researchers Find Treatment Options for Patients Whose Blood Cancer Relapses After CAR-T
Addresses major gap in effectiveness of immunotherapy Mount Sinai Press Release New York, NY - Mount Sinai and Memorial Sloan Kettering Cancer Center (MSK) researchers have identified therapies that can help patients with the blood cancer multiple myeloma who try an...
UC San Diego School of Medicine Finds STEM Cell Rehabilitation Treatment for Spinal Cord Injuries
By University of California - The Guardian UC San Diego School of Medicine’s Translational Neuroscience Institute made its latest breakthrough in the treatment of spinal cord injuries after the culmination of 30 years of research. In a paper published on Aug. 22, a...
Mayo Clinic Researchers ID Potential Gene Marker for Treating Pancreatic Cancer
By Joe Dangor - Mayo Clinic ROCHESTER, Minn. — Researchers at Mayo Clinic Comprehensive Cancer Center have identified a gene marker that may lead to a more effective, precision treatment for pancreatic ductal adenocarcinoma (PDAC). The researcher’s findings are...
CRISPR cancer trial success paves the way for personalized treatments
By Heidi Ledford - Nature ‘Most complicated therapy ever’ tailors bespoke, genome-edited immune cells to attack tumours. A small clinical trial has shown that researchers can use CRISPR gene editing to alter immune cells so that they will recognize mutated proteins...
Monoclonal antibodies preserve stem cells in mouse brains, bring promise for future studies
By Noah Fromson - University of Michigan Health Image caption: Human neural stem cell transplants (green) survive and migrate throughout the mouse brain (blue) when given a novel monoclonal antibody treatment. Michigan Medicine Using antibodies instead of traditional...
Addressing the challenges of chimeric antigen receptor-T cell therapy
By Susan Murphy - Mayo Clinic Chimeric antigen receptor-T cell therapy (CAR-T cell therapy) — a type of immunotherapy that reprograms a patient's T cells to recognize and destroy cancer cells — has revolutionized the treatment of blood cancers. While the technique has...
Cell and Gene Therapy: Current Challenges and the Benefits of Automation
By Anna MacDonald and Sarah Whelan - Technology Networks Cell and gene therapy is a field of personalized medicine, driving the innovation of medicine and revolutionizing the way we treat disease. Gene therapies use DNA or other genetic material to edit a patient's...
Trial of Stem Cell-derived Therapy for Parkinson’s to Open in Sweden
by Margarida Maia, PhD - Parkinson's News Today A request to launch a first Phase 1/2 clinical trial of a stem cell-based therapy in people with Parkinson’s disease has been approved by the Swedish Medical Products Agency. The therapy, called STEM-PD, consists of stem...
A stress test for blood stem cells
by Nature Italy By studying how hematopoietic stem cells respond to age and damage, Raffaella di Micco aims to anticipate the long-term effects of some gene therapies. This is a scene from my daily routine in my lab in Milan where we study hematopoietic stem cells,...
Ground-breaking stem cell procedure restores patient’s mobility and joy for life
By The Ottawa Hospital - The Globe and Mail Treatment developed at The Ottawa Hospital can halt MS progression and potentially reverse symptoms When Geneviève Bétournay developed blurry vision and pain in her hips 12 years ago, she was shocked to be diagnosed with...
Researchers use CRISPR-edited T cells to treat seriously ill children with resistant leukaemia
By Medical News Life Sciences Researchers at Great Ormond Street Hospital for Children (GOSH) and UCL Great Ormond Street Institute of Child Health (UCL GOS ICH) have used CRISPR/Cas9 technology to engineer donor T cells to try to treat seriously ill children with...
Stem Cell Study Shows How Neurons from PTSD Patients React to Stress
By Genetic Engineering & Biotechnology News A study by scientists at the Icahn School of Medicine at Mount Sinai, the James J. Peters Veterans Affairs Medical Center, the Yale School of Medicine, and the New York Stem Cell Foundation Research Institute (NYSCF) has...
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