News and Opinions
Mice Regenerate Ear Tissue When Vitamin A Genetic Switch is Flipped
By Genetic Engineering and Biotechnology News - By flipping an evolutionarily disabled genetic switch involved in vitamin A metabolism, researchers headed by a team at the National Institute of Biological Sciences, Beijing, have enabled ear tissue regeneration in...
Releasing a molecular ‘brake’ may help immune cells better fight cancer
By Van Andel Institute - Grand Rapids, MI - Van Andel Institute scientists and collaborators have discovered a potential treatment target that may re-energize dysfunctional or “exhausted” immune cells in their fight against cancer. The target is an immune checkpoint...
Partial Match Parity: Increasing the Donor Pool for Hematopoietic Stem Cell Transplantation
By: Charlotte Schubert, Ph.D. - University of Miami Miller School of Medicine - Blood cancer patients who may have previously struggled to find a donor for transplantation now have more options. A new study shows that patients achieve good outcomes with an partial...
“Leukemia-on-a-Chip” Offers a New Tool for Screening CAR T-Cell Therapy
By Technology Networks - Chimeric antigen receptor (CAR) T cell therapy represents a breakthrough in cancer treatment. By harnessing the body’s immune system, CAR T therapy provides a powerful, personalized treatment option that can be particularly effective for...
3 progressive MS patients see lower disability with CAR T-cell therapy
by Marisa Wexler - Multiple Sclerosis News Today - A CAR T-cell therapy from Iaso Biotherapeutics was tolerated well and led to marked improvements in disability for three people with progressive forms of multiple sclerosis (MS), according to early data from a Phase 1...
Organ-Chips May Help Unlock the Mystery of ALS
By Christina Elston - Cedars Sinai - Cedars-Sinai’s Lifelike Laboratory Model Is a New Way for Investigators to Study Motor Neurons That Die in Patients With the Neurodegenerative Illness Using stem cells from patients with ALS (amyotrophic lateral sclerosis),...
Japan is helping lead the way in regenerative medicine
By Alex (Guangyao) Xu - The Japan Times - In a quiet operating room on Kyoto University’s medical campus, a team of researchers slipped a syringe of lab-grown neurons into the brain of a living person. Leading the trial was Jun Takahashi, a neurosurgeon with the kind...
FDA blocks new clinical trials that ship cells from US to China
By Nick Paul Taylor - Fierce Biotech - The FDA has stopped new clinical trials that export American citizens’ living cells from the U.S. to “China and other hostile countries for genetic engineering and subsequent infusion” back into American patients. Officials said...
Francis Collins Reflects on Human Genome Project’s 25th Anniversary
By Alex Philippidis , Fay Lin, PhD and Kevin Davies, PhD - Genetics and Biotechnology News - The reference genome was a “bridge into the future,” but there is still much work that needs significant support. 25 years ago, Francis Collins, MD, PhD, led the international...
FDA Greenlights Twice-A-Year HIV Prevention Drug
By Antonio Pequeño IV - Forbes - Yeztugo, a twice-a-year antiviral shot to prevent HIV, was approved by the Food and Drug Administration on Wednesday, marking a major advance in battling AIDS. Key Facts The drug (which has the generic name lenacapavir) will become...
New Immunotherapy Reverses Cholesterol Damage in Heart Cells
By Sant Pau Research Institute - SciTechDaily - A new antibody treatment prevents cholesterol buildup in heart mitochondria and restores energy production, offering hope for future heart disease therapies. An international team of researchers has uncovered how...
Designing blood vessels for 3D printed hearts
By Stanford Report - Stanford researchers have developed a faster, more precise way to model and print vascular systems, solving a critical challenge in fabricating transplantable organs from patients’ own cells. There are more than 100,000 people on organ transplant...
People With Severe Diabetes Are Cured in Small Trial of New Drug
By Gina Kolata - New York Times - Most in a small group of patients receiving a stem cell-based infusion no longer needed insulin, but the drug may not suit those with more manageable type 1 diabetes. A single infusion of a stem cell-based treatment may have cured 10...
Germany calls for medicine to treat aging, not just disease
By Eleanor Garth - Longevity.Technology - Leopoldina issues policy paper urging integration of geroscience into national healthcare and research infrastructure. Germany’s National Academy of Sciences Leopoldina has published a detailed policy paper calling for a...
Dozens of states sue to block the sale of 23andMe personal genetic data
By The Associated Press - PORTLAND, Ore. — Twenty-seven states and the District of Columbia on Monday filed a lawsuit in bankruptcy court seeking to block the sale of personal genetic data by 23andMe without customer consent. The lawsuit comes as a biotechnology...
Blocking a single enzyme rewires limb regrowth in axolotls
By Vijay Kumar Malesu - Medical life Sciences News - In a recent study published in the journal Nature Communications, researchers in the United States explored how cytochrome P450 family 26 subfamily B member 1 (CYP26B1)-mediated retinoic acid (RA) breakdown...
Son’s diabetes diagnosis sent scientist on quest for cure
by Kermit Pattison - The Harvard Gazette - Decades later, Doug Melton and team are testing treatment that could make insulin shots obsolete. Doug Melton’s life irrevocably changed the day his child was diagnosed with a life-threatening disease. But unlike most other...
Research Spotlight: Preventing stalling to improve CAR-T cells’ efficacy against tumors
By Mass General Brigham - Marcela Maus, MD, PhD, director of the Cellular Immunotherapy Program and the Paula J. O'Keeffe Endowed Chair of the Mass General Cancer Center, is senior author and Stefanie Bailey, PhD, Hana Takei, and Giulia Escobar, PhD of the Krantz...
Stem cell platform aims to recreate brain’s immune system using lab-grown human microglia cells
by Harvard University - Microglia are a specialized type of immune cell that accounts for about 10% of all cells within the brain and spinal cord. They function by eliminating infectious microbes, dead cells, and aggregated proteins, as well as soluble antigens that...
After groundbreaking CRISPR therapy, a homecoming
By Meghana Keshavan - Stat News - From my colleague Jason Mast: KJ Muldoon, the first infant treated with a personalized gene-editing drug, has been discharged from the hospital for the first time in his life, the Children’s Hospital of Philadelphia announced Tuesday....
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