News and Opinions
Blocking a single enzyme rewires limb regrowth in axolotls
By Vijay Kumar Malesu - Medical life Sciences News - In a recent study published in the journal Nature Communications, researchers in the United States explored how cytochrome P450 family 26 subfamily B member 1 (CYP26B1)-mediated retinoic acid (RA) breakdown...
Son’s diabetes diagnosis sent scientist on quest for cure
by Kermit Pattison - The Harvard Gazette - Decades later, Doug Melton and team are testing treatment that could make insulin shots obsolete. Doug Melton’s life irrevocably changed the day his child was diagnosed with a life-threatening disease. But unlike most other...
Research Spotlight: Preventing stalling to improve CAR-T cells’ efficacy against tumors
By Mass General Brigham - Marcela Maus, MD, PhD, director of the Cellular Immunotherapy Program and the Paula J. O'Keeffe Endowed Chair of the Mass General Cancer Center, is senior author and Stefanie Bailey, PhD, Hana Takei, and Giulia Escobar, PhD of the Krantz...
Stem cell platform aims to recreate brain’s immune system using lab-grown human microglia cells
by Harvard University - Microglia are a specialized type of immune cell that accounts for about 10% of all cells within the brain and spinal cord. They function by eliminating infectious microbes, dead cells, and aggregated proteins, as well as soluble antigens that...
After groundbreaking CRISPR therapy, a homecoming
By Meghana Keshavan - Stat News - From my colleague Jason Mast: KJ Muldoon, the first infant treated with a personalized gene-editing drug, has been discharged from the hospital for the first time in his life, the Children’s Hospital of Philadelphia announced Tuesday....
How our bones are repaired by skeletal stem cells: Scientist discover four major subtypes
by Sarah Williams, Stanford University - MedicalXpress - Whether you are a competitive athlete or an older adult, strong bones are essential—not only for movement, but also for overall health. Now, a new study has shed new light on how our bones are maintained and...
No More Transplants? New Gene Therapy Targets Blood Stem Cells Directly
By Fondazione Telethon - SciTechDaily - Researchers have identified an early postnatal window that allows gene transfer to circulating blood stem cells, advancing the development of potential treatments for genetic disorders. A team of scientists from the San...
Stem cell therapies advance in Parkinson’s disease and beyond
By Natalie Healey - Nature Medicine - Landmark trials using stem cells to treat Parkinson’s disease in the USA and Japan mark a turning point for cell therapy in neurodegeneration. Similar approaches to Alzheimer’s disease and amyotrophic lateral sclerosis are also...
The Potential Impact Of U.S. Tariffs On The Biotech Sector: Manufacturing, Funding, And Clinical Trials
By Raymond Forslund, PhD - Clinical Leader - The imposition of tariffs by the United States government has introduced significant uncertainties across various industries, including biotechnology. This white paper examines the potential ramifications of these tariffs...
Florida lawmakers approve bill to improve access to some unapproved stem cell therapies
By Rick Mayer - WUSF-NPR - Health News Florida The measure authorizes physicians to perform the treatments for orthopedics, wound care or pain management with strict requirements to ensure safety and ethics. Before the annual session ended last week, the Florida...
An Avatar for Studying Human Health: Tissue Chips
By NASA - High school student Kyle Benjamin speaks with Dr. Lisa Carnell, program scientist of NASA’s Translational Research Program, about her work using tissue chips to study human biology in space -- and what it could mean for personalized medicine back on Earth....
Stem cell transplant transforms life of toddler with beta thalassemia major
By Lynn Nicho;ls - Stanford Medicine - From Frequent Transfusions to a Cure for Beta Thalassemia Wade Huynh, age 3, was born with a serious blood disorder, and he needed a stem cell transplant to thrive. Luckily, he didn’t need to look far for a donor match—just...
One step closer to 3D printing inside the body
By Healthcare-in-Europe.com What if doctors could precisely print miniature capsules capable of delivering cells needed for tissue repair exactly where they are needed inside a beating heart? A team of scientists led by Caltech has taken a significant step toward that...
Gene-edited stem cells aim to reverse rheumatoid arthritis
by Max G. Levy, PhD - Drug Discovery News - At the root of anything good or bad in the human immune system is a question about recognition. When the immune system functions correctly, it clocks unrecognized bacteria and viruses. When it misbehaves, immune cells...
Cracking the code to scalable cell and gene therapy
by Drug Target Review - Cell and gene therapy (CGT) is advancing rapidly, offering new treatments for complex conditions such as cancer and genetic disorders. As these therapies evolve, the demand for more efficient and reliable methods of cell expansion – an...
New Cell Therapy For Resistant Hodgkins Patients
By Derek Lowe - Science - Here’s some more good news on the immuno-oncology front. Hodgkin lymphoma (HL) is one of those cancer types whose prognosis is in the “A lot better than it used to be, but. . .” category. There are several varieties (with the “classic” form...
The stem cell race for Parkinson’s disease: Recent studies show significant promise
By Willow Shah-Neville - LabBioTech - Parkinson’s disease is an extremely complex condition to treat. Although there are medications available that can help relieve symptoms, there are still no approved therapies that slow down the progression of the underlying...
Federal appeals court sends CRISPR-Cas9 patent case back to patent office for reconsideration
By Robert Sanders - UC Berkley News - In a decision released today (May 12), the U. S. Court of Appeals for the Federal Circuit in Washington, D.C., ordered the U.S. Patent and Trademark Office’s Patent Trial and Appeal Board (PTAB) to reconsider its 2022 interference...
Embryonic macrophages found to control blood stem cell numbers in bone marrow
by Kerstin Wagner, Leibniz - MedicalXpress.com - Scientists at the Leibniz Institute on Aging—Fritz Lipmann Institute (FLI) in Jena have discovered a previously unknown function of immune cells in the bone marrow. Embryonic macrophages—specialized phagocytes of the...
Biotech Tango dances away from preclinical work to extend cash runway, while Avalo lays out spending options
By Nick Paul Taylor - Fierce Biotech - Biotech bank balances were again in focus Monday morning, with Tango Therapeutics cutting preclinical work to stretch its cash runway and Avalo Therapeutics outlining options for preserving its money. Tango extended its cash...
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