News and Opinions
Lab-made muscle: New laser tech grows real human tissues to replace lab rats
by Mrigakshi Dixit - Interesting Engineering - Think of a future where injuries heal faster, diseases are cured more effectively, and lab-grown meat is a reality. This future is one step closer, thanks to the innovative work of Dr. Hao Liu from ETH Zurich. Liu uses...
Reversing lung scarring with a shot of stem cells
by Andrew Saintsing, PhD - Drug Discovery News - When the world ground to a halt in 2020, news outlets regularly featured stories about how COVID-19 wreaked havoc on patients’ lungs. In millions of cases, an initial cough developed into full-blown pneumonia, which...
UCLA researchers engineer experimental drug for preventing heart failure after heart attacks
By Ani Vahradyan - UCLA Broad Stem Cell Research Center - Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a first-of-its-kind experimental therapy that has the potential to enhance heart repair...
Do stem-cell transplants increase cancer risk? Long-lived recipients offer clues
By Smriti Mallapaty - Nature - Ever since the first blood-forming stem cells were successfully transplanted into people with blood cancers more than 50 years ago, researchers have wondered whether they developed cancer-causing mutations. A unique study1 on the...
Re-engineered, blue light-activated immune cells penetrate and kill solid tumors
by Pennsylvania State University - MedicalXpress - Immunotherapies that mobilize a patient's own immune system to fight cancer have become a treatment pillar. These therapies, including CAR T-cell therapy, have performed well in cancers like leukemias and lymphomas,...
Microenvironment-responsive nanomedicines: a promising direction for tissue regeneration
By BMC - Military Medical Research - Severe tissue defects present formidable challenges to human health, persisting as major contributors to mortality rates. The complex pathological microenvironment, particularly the disrupted immune landscape within these defects,...
Life Without Sickle Cell Beckons Boy Who Completed Gene Therapy
By Gina Kolata - New York Times - After 44 days, Kendric Cromer, 12, left the hospital. While his family feels fortunate that he was the first to receive a treatment, their difficult experiences hint at what others will be up against. Kendric Cromer, 12, left...
Neuroscientists discover a mechanism that can reactivate dormant neural stem cells
by Duke-NUS Medical School - MedicalXpress - An international team of neuroscientists, led by Duke-NUS Medical School, have uncovered a mechanism that controls the reactivation of neural stem cells, which are crucial for repairing and regenerating brain cells. The...
Human skin map gives ‘recipe’ to build skin and could help prevent scarring
by Wellcome Trust Sanger Institute - MedicalXpress - For the first time, researchers have created a single cell atlas of prenatal human skin to understand how skin forms, and what goes wrong in disease. Researchers from the Wellcome Sanger Institute, Newcastle...
Comparative analysis of single versus tandem autologous stem cell transplantation in patients with multiple myeloma in Korea: the KMM2102 study
By - Nature - Despite treatment advances, multiple myeloma (MM) remains incurable1. High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is considered the standard treatment for eligible patients2,3. Moreover, ASCT is reportedly effective and...
A new era of COVID-19 brings new outlooks for cellular therapy recipients
By A Donlan - Fred Hutch Cancer Center - During the COVID-19 pandemic, it quickly became clear that certain populations were particularly at risk for severe disease. Individuals undergoing hematopoietic cell transplants (HCT) or chimeric antigen receptor T-cell (CART)...
Researchers identify gene crucial to blood stem cell regulation, growth
By Danielle H. Cho - Daily Bruin - UCLA researchers have found a gene that may have implications for treating blood-related genetic diseases and cancers. All types of blood cells come from blood stem cells, said Júlia Aguadé-Gorgorió, the first author of the paper...
Scientists Use CRISPR Tools to Safely Disable Gene Mutation Linked to Advanced Skin Cancer
By Christiana Care News - In a potential advance for melanoma patients, researchers at ChristianaCare’s Gene Editing Institute have used CRISPR gene editing tools to disable a gene mutation often seen in aggressive forms of this dangerous skin cancer that renders...
Scientists Use Human Stem Cells to Restore a Monkey’s Vision
by Maggie Harrison Dupré - Neoscope - Scientists have successfully used human stem cells to patch a hole in a monkey's retina, restoring the primate's vision and marking a successful step forward in the quest to treat age-related vision loss. As detailed in a study...
Cell and gene therapy approvals drive paradigm change in manufacturing
by Irena Maragkou - Pharmaceutical Technology - Innovative cell and gene therapies (CGTs) have significantly disrupted the treatment landscape for several genetic diseases. In recent years, the number of CGT approvals has been on an upward trajectory, with there being...
CAR T-Cell Therapy: Pathology Is Key to This Revolutionary Cancer Treatment
by Isabella Backman - Yale School of Medicine - CAR T-cell therapy, officially known as chimeric antigen receptor (CAR) T-cell therapy, is among the newest cancer treatments that harness our immune system— the powerful network of cells, tissues, and organs that fights...
World’s first ovarian cancer vaccine being developed in UK ‘could wipe out the disease’
By Sky News - The world's first ovarian cancer vaccine could wipe the disease out, researchers have said. OvarianVax is a vaccine that teaches the immune system to recognise and attack the earliest stages of ovarian cancer. It's being developed by scientists at the...
Purdue and UPenn research finds link between aging, fat accumulation in the brain
By Purdue University - With age, some cells in the brain enter a state of senescence: rather than dying or regenerating by dividing, they just linger, alive, but functioning less effectively than normal cells. Senescence in the brain has been linked to cognitive...
Selling ‘snake oil’? The days are numbered for stem cell clinics
By Alexis Rivas - NBC Channel 7 News, San Diego CA - A federal appeals court handed the FDA power to shut down unproven stem cell treatments The future of stem cell clinics across San Diego County, California, and the country are at risk. A federal appeals court in...
“Functional cure” for diabetes restores insulin production with stem cells
By Michael Irving - New Atlas - A patient with type 1 diabetes has been functionally cured of the disease, requiring no insulin doses for over a year. The treatment involves growing and transplanting new insulin-producing cells from the patient’s own stem cells. Type...
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