by Michael Carey, PhD – UCLA Health –
A study by UCLA scientists has uncovered significant insights into stem cell aging, specifically in neural stem and progenitor cells (NSPCs) in the mouse brain. The research reveals that NSPC aging is primarily characterized by a reduced efficiency in producing proliferative cells, rather than alterations in cell lineage. Importantly, the study identifies the downregulation of age-dependent genes due to epigenetic deregulation as a key mechanism driving this aging process, offering potential avenues for rejuvenating aging stem cells. The study is published in Nature Aging.